Collect all five bags in route order

This is the altered Medical Centre in Part 3, “Many Into One.” Two bags open the route and are consumed; they are not missing final ingredients.

BagUseContinue by
Alan DuncanInsert into the SW door mechanismCollect Sarah Watson.
Sarah WatsonKeep for the final machineCollect Ward W Master Key.
Lesley GreerInsert into the DP door mechanismUse Ward W access and the ladder to reach this section.
George McEwanKeep for the final machineCollect Ward P Master Key.
Matthew ClarkKeep for the final machineCollect after the elevator drops to the lower area.

After taking Matthew’s bag, operate both manual-release wheels to open the exit gates. One wheel alone does not complete the escape.

First access bag · 0:56 ▶ · Matthew and the exit · 2:43 ▶

Reference: GamesRadar+ — blood transfusion, AllThings.How — blood puzzle, PowerPyx — full story & puzzle solutions.

Set the three final slots

These clues describe patient symptoms, not blood-group compatibility. GameHelpBase diagram; not a map or game screenshot.
SlotBagClue
LeftSarah WatsonRegular pulse; head wound
MiddleMatthew ClarkConfused speech; obeys commands
RightGeorge McEwanSecond- and third-degree burns

Use the switch near the room door after installing all three. The next stage is blood-type routing, not another bag-order puzzle.

Final bag placement · 3:17 ▶

Connect the compatible donors to Ordell

Read Simon’s bracelet: the patient is Ordell A+. This puzzle accepts O−, O+, A− and A+ donor groups. Match the chart beside the machine to its initials.

Target paths, not exact ring angles. Trace each complete route. GameHelpBase diagram; not a map or game screenshot.
  1. Rotate the rings until TF, HM and SW each have an uninterrupted connection to the centre.
  2. Check that every other donor path is blocked. A correct elbow can still connect an unwanted branch elsewhere.
  3. Select the central Ordell control to start the transfusion.
Compare continuous paths rather than a single junction. IGN · 4:25 ▶

Chart and wheel · 3:31 ▶ · Final alignment and activation · 4:25 ▶

Reference: GamesRadar+ — blood transfusion, AllThings.How — blood puzzle.

If the machine will not start

  1. Check the three named bags and use the door-side switch for stage one.
  2. Re-read Ordell’s bracelet and the donor chart for stage two.
  3. Use only TF, HM and SW, then inspect every full path to the centre.
  4. Activate Ordell after aligning the wheel. A solved-looking display without that interaction does not finish the task.

Video walkthrough

Every ▶ time link plays in the player below. Choose another time to continue in the same player.

Blood Transfusion Puzzle SolutionIGN · Watch on YouTube ↗

Sources & image credits

View sources and credits

Reviewed October 9, 2026. Written instructions were compared with the cited gameplay and current official information.

Gameplay frames: IGN, at the captioned times. Diagrams: GameHelpBase. They explain the task and are not game screenshots or exact maps.