Start with the right hospital state

Where you areWhat opens the next route
Outside as Zoe, Chapter 5Medical Security Note → call Dr. Glenn → garage-office switch.
Outside as Simon, Chapter 6Town Square pistol choice → Flemington Street scalpel door → apartment/scaffolding route.
Ordinary hospital, Chapter 7Chapman Records Room code 2605; this is a medicine errand.
Medical Center – Different, Chapter 8Blood-bag door machines, ward master keys and two release wheels. The ordinary ward map does not describe this layout.

The pharmacy and family clinic are separate Shorefront buildings. Being at their entrances does not mean you have reached the Medical Centre. Read the region title on your map before following any room numbers.

Get through the exterior routes

Zoe: inspect the security-booth window outside the Medical Centre. Call 496 0556 from the phone booth down the street. The reported menu sequence is 3 → 2 → 2 → 1. After access is granted, enter the rear parking garage and its office; press the wall button beside the phone to open the gates.

Simon: in Chapter 6, return to the Town Square gift and choose Yes to taking the pistol. The town changes, opening the story route. Use the Scalpel at the Flemington Street door, then follow the apartment route south of the Medical Centre. Go up to the scalpel-locked apartment 2/2, through the scaffolding connection, and continue through the apartment building toward the hospital. The earlier security-call sequence belongs to Zoe’s chapter.

Compare the chapter starts in 18:08 — Zoe: Rounds ▶ and 25:26 — Journey to Medical ▶. These are the creator’s chapter markers.

Find the Archive / Records Room

  1. In the ordinary hospital, collect the map from the wall near Surgery. Look for Chapman Ward, not Victoria Ward.
  2. For the clue, take the stairs by Patient Room A to Chapman’s first floor. Search the northwest Office noticeboard beside the computer; the note gives 2605.
  3. Return to Chapman’s ground floor and its northwest Records Room double doors. Enter 2, 6, 0, 5 on the adjacent keypad.
  4. Inside, open the metal cabinet and its green medical container. Take Hydroxalene for the treatment procedure.
The Records Room doorway, with PowerPyx’s code annotation. Game screenshot: PowerPyx, Part 3 illustrated guide.

The “archive department” search refers here to the room labelled Records Room. The medicine comes from Chapman’s ground floor; Victoria’s Pharmacy Store holds another medicine. Use the patient treatment guide for all three pickups and pump settings.

Collect the bags and get out of P / D

  1. Pick up the altered map at the upper-floor counter. Alan Duncan’s bag opens the S.W. door. Follow S/W, collect Sarah Watson’s bag, take the Ward W Master Key from lower-floor room 04, then unlock room 13.
  2. Climb the ladder from lower room 13 into upper room 12 for Lesley Greer’s bag. Bring it to the central D.P. door machine and use its switch.
  3. In D, go via room 03 into room 02 and operate the lift button to send Matthew Clark’s bag down. In P, crawl through the vent on the north wall of upper room 06, then drop into lower room 10 for George McEwan’s bag and the Ward P Master Key.
  4. Use that key to open P room 03 and retrieve Matthew’s bag from the lift doors. Having all bags does not release the outside door.
  5. Return to D’s upper floor. Operate the wheels in rooms 05 and 10. Check both before returning to the central area. Use cover and the nearby hiding places while the pursuer moves away.
Original progression schematic. Room and item sequence only; not a floor map.

Finish the central blood-transfusion machine after getting out: place Sarah, Matthew and George in their required slots, then solve Simon’s compatible-donor circuit. See blood bags and final transfusion for the final machine. Room 204’s key opens the next story door.

If a door still will not open

SymptomCheck
Still locked outsideMatch Zoe’s security-call stage or Simon’s Chapter 6 altered-town stage first.
Cannot enter RecordsConfirm Chapman ground floor and 2605. The Surgery/X-ray keypad is a different door.
Cannot retrieve Matthew’s bagSend the lift down from D room 02 first; open P room 03 with the master key.
Ward exit stays closedTurn both upper D wheels, in rooms 05 and 10. Bag collection alone does not operate them.

Video walkthrough

Full game walkthrough and puzzle solutions

PowerPyx · Watch on YouTube ↗

Sources & image credits

Source links and credits

Source footage and game images are credited beside the relevant figures. This guide does not claim a personal playthrough.

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